Table 3.
Ex-vivo biodistribution of [18F]flumazenil at 5, 10, 30, 60, 120, and 240 min after injection in SD rats. The percentage dose per gram (%ID/g) was calculated by comparing the sample counts with the count of the diluted initial dose. In the calculated SBR, different brain regions are compared to the pons/medulla.
| %ID/g | 5 min | 10 min | 30 min | 60 min | 120 min | 240 min | |
|---|---|---|---|---|---|---|---|
| Cerebellum | 2.22 ± 0.12 | 0.74 ± 0.04 | 0.07 ± 0.00 | 0.02 ± 0.00 | 0.01 ± 0.00 | 0.00 ± 0.00 | |
| Pons/Medulla | 1.80 ± 0.19 | 0.60 ± 0.06 | 0.06 ± 0.01 | 0.02 ± 0.00 | 0.01 ± 0.00 | 0.00 ± 0.00 | |
| Striatum | 3.27 ± 0.32 | 1.09 ± 0.11 | 0.11 ±0.01 | 0.04 ± 0.00 | 0.02 ± 0.00 | 0.01 ± 0.00 | |
| Cortex (Amyglada) | 5.28 ± 0.60 | 2.16 ± 0.39 | 0.38 ± 0.02 | 0.06 ± 0.01 | 0.03 ± 0.00 | 0.01 ± 0.00 | |
| Hippocampus | 4.57 ± 0.56 | 1.82 ± 0.19 | 0.25 ± 0.01 | 0.05 ± 0.00 | 0.03 ± 0.00 | 0.01 ± 0.00 | |
| Thalamus | 4.22 ± 0.41 | 1.61 ± 0.14 | 0.14 ± 0.00 | 0.05 ± 0.00 | 0.02 ± 0.00 | 0.01 ± 0.00 | |
| Hypothalamus | 3.71 ± 0.18 | 1.34 ± 0.06 | 0.12 ± 0.00 | 0.04 ± 0.00 | 0.02 ± 0.00 | 0.01 ± 0.00 | |
| SBR | 5 min | 10 min | 30 min | 60 min | 120 min | 240 min | |
| Cerebellum | 0.25 ± 0.18 | 0.36 ± 0.26 | 0.16 ± 0.15 | 0.36 ± 0.14 | 0.32 ± 0.07 | 0.71 ± 0.32 | |
| Striatum | 0.84 ± 0.37 | 0.92 ± 0.34 | 0.91 ±0.29 | 1.00 ± 0.36 | 0.94 ± 0.24 | 0.98 ± 0.33 | |
| Cortex (Amyglada) | 1.96 ± 0.49 | 2.65 ± 0.85 | 5.32 ± 0.82 | 2.22 ± 0.42 | 2.14 ± 0.43 | 1.71 ± 0.51 | |
| Hippocampus | 1.55 ± 0.37 | 2.06 ± 0.41 | 3.24 ± 0.52 | 1.78 ± 0.32 | 1.71 ± 0.41 | 1.73 ± 0.87 | |
| Thalamus | 1.37 ± 0.37 | 1.70 ± 0.40 | 1.37 ± 0.36 | 1.57 ± 0.31 | 1.51 ± 0.30 | 1.53 ± 0.58 | |
| Hypothalamus | 1.08 ± 0.26 | 1.25 ± 0.28 | 1.15 ± 0.14 | 1.26 ± 0.21 | 1.20 ± 0.19 | 1.02 ± 0.42 | |