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Infection parameters as assessed in mice 6, 24 and 72 h post induction of UTI. Animals at the 6 h timepoint were pre-treated at T = 0, while animals at the 24 h timepoint were treated at T = 6 h post inoculation. Bacterial burden was assessed in the bladder at 24 h (A), and within the kidneys at 6 and 24 h (B). Systematic parameters were also assessed, including spread to spleen (C) and blood (D) at 6 and 24 h. Data presented as mean ± SD, * p < 0.05.
