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. 2023 May 22;15(5):1562. doi: 10.3390/pharmaceutics15051562

Figure 9.

Figure 9

In vivo toxicity analysis of ginkgolide-B-loaded GB–PPNPs in zebrafish embryo and MPTP-induced murine model of PD. (A) Zebrafish embryos were treated with different concentrations of GB–PPNPs (50, 100, 200, and 400 μg/mL), and at 96 hpf, the embryo morphology was visualized via microscopy. The survival rates, hatching rates, heart rates, and zebrafish body length were calculated. Scale bar: 500 μm. (C–H) Impact of GB–PPNPs on the striatum with determined levels of (A) MDA, (B) SOD, (C) GSH-Px (means ± SD, n = 4), (D) dopamine, (E) DOPAC, and (F) HVA (n = 7). * p < 0.05 and ** p < 0.01 correspond to different treatments vs. MPTP. # p < 0.05 and ## p < 0.01 correspond to GB–PPNPs vs. GB. Adapted with permission from [198]. Copyright {2022} Science-HHS Public Access (PubMedCentral).