Table 6.

Natural protein in sonication-triggered SF hydrogels.

Natural Protein	Delivery System	Experiment Design	Outcome	Reference
Collagen	Collagen hydrogel loaded with Rat pulp cells marked with indium-111-oxine	Implantation in the rat emptied pulp chamber.	Functioning fibroblasts, neovasculature, and nerve fibers were seen in the collagen hydrogel one month after insertion.	[131]
Collagen	Blends with nano keratin, and hydroxyapatite	Histomorphometry on critical size defects in rat calvaria	bio-compatibility, biodegradability, and increased density of newly formed bone	[132]
Gelatin	Cross-linked gelatin hydrogel micro particles were encapsulated with fibroblast growth factor 2 (FGF-2) and mixed with collagen sponge pieces	Detection of expression of DSPP (Dentin Sialophosphoprotein)	Regulated FGF2 release from gelatin hydrogels resulted in the production of dentin-like particulates with dentin defects above exposed pulp.	[133]
Fibrin	Incorporation of clindamycin loaded Poly (D, L) Lactic Acid nanoparticles (CLIN-loaded PLA NPs).	Cell viability and antimicrobial assay	Fibrin hydrogels incorporating CLIN-loaded PLA NPs reduced bacterial colonization and had an antimicrobial property towards E. faecalis. In cellularized hydrogels, DPSC survival and type I collagen production were comparable to the unmodified groups.	[134]
Silk Fibroin	Silk Fibroin/Cellulose Hydrogel	Cell viability	The hydrogels promote MC3T3 cell development into osteoblasts and are predicted to be a promising matrix for osteogenesis.	[135]