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. 2023 Apr 23;11(5):401. doi: 10.3390/toxics11050401

Table 1.

Establishment of cumulative assessment groups of pesticides for their effects on the nervous system, the thyroid and the developing foetus.

Endpoint CAG Level Reference
CAG Level 1
(Organ/
Organ System)		 CAG Level 2(
Refinement on
Phenomenological Effect)
Neurotoxicity (acute) Pesticide active substances affecting the nervous system, either central or peripheral Substances with different general targets concerning neurotoxicity:
  • -

    Effects on motor division of the nervous system (n = 119)

  • -

    Effects on sensory and autonomic function (n = 101)

  • -

    Neurochemical effects (brain and/or erythrocyte acetylcholinesterase (AChE) inhibition) (n = 47)

  • -

    Neuropathological changes in neural tissue (n = 19)

 [82,83]
Neurotoxicity (chronic) Pesticide active substances producing chronic effects on the nervous system Substances with chronic erythrocyte acetylcholinesterase inhibition (n = 47) [84]
Thyroid toxicity All substances affecting the thyroid hormone system (gland or hormones) Different general targets, including thyroid tissue and associated hormone systems:
  • -

    Substances affecting the thyroid parafollicular cells (C-cells) and/or calcitonin system (CAG2A)

  • -

    Substances affecting thyroid follicular cells and/or the thyroid hormone (T3/T4) system (CAG2B)

 [82,85]
Craniofacial alterations (acute) Pesticide active substances and their metabolites causing craniofacial alterations
  • -

    Substances (n = 39) causing alterations due to abnormal skeletal development (CAG-DAC)

  • -

    Substances (n = 41) causing head soft tissue alterations and brain neural tube defects (CAG-DAH)

 [86]

# includes effects on locomotor activity, muscle strength, coordination and equilibrium.