Table 2.
Inhibition of isolated PDK1 isoform or HSP90. IC50 values were calculated by a four-parameter analyzed logistic model (p < 0.05). DCA and DAP were reported as reference compounds. Data represent mean values from 3 independent experiments. S.D. = standard deviation.
| Cpd | IC50 (µM) ± S.D. PDK1 | IC50 (µM) ± S.D. HSP90 | Cpd | IC50 (µM) ± S.D. PDK1 | IC50 (µM) ± S.D. HSP90 |
|---|---|---|---|---|---|
| 4a | 0.30 ± 0.10 | - | 5a | 0.32 ± 0.10 | - |
| 4b | 0.33 ± 0.05 | - | 5b | 0.21 ± 0.07 | - |
| 4c | 0.26 ± 0.07 | - | 5c | 0.27 ± 0.08 | - |
| 4d | 0.04 ± 0.02 | 0.06 ± 0.02 | 5d | 0.05 ± 0.02 | 0.07 ± 0.01 |
| 4e | 0.29 ± 0.06 | - | 5e | 0.32 ± 0.10 | - |
| 4f | 0.12 ± 0.04 | 0.10 ± 0.03 | 5f | 0.08 ± 0.02 | 0.11 ± 0.04 |
| 4g | 0.19 ± 0.04 | - | 5g | 0.29 ± 0.10 | - |
| 4h | 0.06 ± 0.02 | - | 5h | 0.05 ± 0.03 | 0.09 ± 0.03 |
| 4i | 0.33 ± 0.10 | - | 5i | 0.31 ± 0.07 | - |
| 4j | 0.18 ± 0.06 | - | 5j | 0.04 ± 0.02 | 0.18 ± 0.04 |
| DCA | 15,890 ± 256 | 29,740 ± 558 | DAP | 212 ± 48 | 698 ± 83 |