Table 2.
Epitopes of HBHA and MTP predicted by the Immune Epitope Database (IEDB).
| Type of Peptides | Location | Peptide Sequence |
|---|---|---|
| CD4+ T cell epitopes | HBHA(40–54) | EETRTDTRSRVEESR |
| HBHA(181–195) | AAAKKAPAKKAAAKK | |
| HBHA(175–189) | AAPAKKAAAKKAPAK | |
| HBHA(163–177) | AAPAKKAAPAKKAAP | |
| MTP(27–41) | AQSAAQTAPVPDYYW | |
| MTP(63–77) | DFHRDSDGPDHSRDY | |
| MTP(66–80) | RDSDGPDHSRDYPGP | |
| MTP(88–102) | DDPGAAPPPPAAGGG | |
| CD8+ T cell epitopes | HBHA(37–45) | ERAEETRTD |
| HBHA(55–63) | ARLTKLQED | |
| HBHA(113–121) | QSFEEVSAR | |
| HBHA(191–199) | AAAKKVTQK | |
| HBHA(153–161) | KLVGIELPK | |
| MTP(32–41) | QTAPVPDYYW | |
| MTP(39–47) | YYWCPGQPF | |
| MTP(94–102) | PPPPAAGGG | |
| B cell epitopes | HBHA(62–79) | EDLPEQLTELREKFTAEE |
| HBHA(107–121) | ERLRSQQSFEEVSAR | |
| HBHA(124–135) | GYVDQAVELTQE | |
| HBHA(146–153) | AVGERAAK | |
| HBHA(160–195) | PKKAAPAKKAAPAKKAAPA KKAAAKKAPAKKAAAKK |
|
| MTP(30–39) | AAQTAPVPDY | |
| MTP(55–80) | WDPYTCHDDFHRDSDGPD HSRDYPGP |
|
| MTP(84–100) | GPVLDDPGAAPPPPAAG |
Notes. T cell and B cell epitopes of HBHA and MTP were predicted by IEDB; the data here suggest that selected sequences were rich in T and B cell epitopes.