Table 3.
Serum antibodies against HBHA in mice immunized with BCG, LV20, and HBHA.
| Groups | IgG | IgG1 | IgG2c | IgG2c/IgG1 |
|---|---|---|---|---|
| PBS | - | - | - | - |
| BCG | 2.90 ± 0 | 2.30 ± 0 | 2.30 ± 0 | 1.00 |
| HBHA/DP | 4.21 ± 0.17 * | 3.20 ± 0.30 * | 4.21 ± 0.35 * | 1.32 |
| LV20 | 3.71 ± 0.17 *# | 2.60 ± 0 # | 2.60 ± 0.30 # | 1.00 |
| LV20/DP | 4.01 ± 0.17 * | 3.20 ± 0 * | 3.00 ± 0.17 *# | 0.94 |
Note: Forty-two days after the last immunization and the titers of anti-HBHA antibody were detected by ELISA. At least three mice per group. Mean ± SD, * p < 0.05 vs. BCG group; # p < 0.05 vs. HBHA/DP group.