Table 3.
Cases with positive FISH
| Case |
FISH signals (%) |
IHC H-score TMA/Fullslide | IHC heterogeneity | DNA-NGS | RNA-NGS | Histology | pStage | Age/ sex |
Smoking status/ Pack-year |
|
|---|---|---|---|---|---|---|---|---|---|---|
| D4D6 | SP384 | |||||||||
| 1 | 39 | 240/300 | 300/300 | No |
TP53 AKT2 CNV |
ROS1-CD74 | Adenocarcinoma (mucinous component) | IIb | 75.1/male | Former smoker/12.3 |
| 2 | 28 | 0/0 | 0/0 | No | Fail | Fail | Squamous carcinoma | IIIa | 69.4/male | Former smoker/34.5 |
| 3 | 16 | 0/0 | 0/0 | No | Fail | Negative | Adenosquamous | IIb | 58.1/female | Current smoker/55 |
| 4 | 64 | 300/300 | 300/300 | No | SETD2, TSC2, TP53 | ROS1-CD74 | Adenocarcinoma (Solid) | IIIa | 61.6/female | Never smoker/0 |
| 5 | 53 | 200/300 | 200/300 | No | PTCH1, TP53 | ROS1-CD74 | Adenocarcinom (mucinous component) | IIb | 61.7/female | Current smoker/23.5 |
In the column FISH signals we report the sum of the isolated 3`signal, isolated 5`signal and split signals divided on the total number of signals (the equation is described under Methods and in Additional file 1)