TABLE 3.
Neutrophil-Related Parameters for Rhesus Macaques after Total-Body γ Irradiation
| Dose (Gy) | Animal ID and gender | Survival day | Neutropenia (≤0.5 × 103 /μl) |
||
|---|---|---|---|---|---|
| Neutrophil nadir/(study days)a | Durationb | Recovery >0.5 × 103 cells/μLc | |||
|
| |||||
| 6.0 | RA2580M | 60 | 0.01 (16) | 6–22 (17 days) | 24 |
| RA2445M | 60 | 0.01 (12) | 10–18 (9 days) | 20 | |
| RA0529F | 60 | 0 (12) | 6–20 (15 days) | 22 | |
| RA2740F | 60 | 0.01 (12) | 6–20 (15 days) | 22 | |
| RA0724F | 14 | 0.01 (12) | * | Deceased | |
| RA0521F | 13 | 0 (12) | * | Deceased | |
| Meand | - | 0.0067 ± 0.0021 | 14 ± 1.73 | 22 ±0.82 | |
| Range | - | 0–0.01 | 9–17 | 20–24 | |
| 6.5 | RA1547M | 60 | 0.02 (16) | 6–18 (13 days) | 20 |
| RA2576M | 60 | 0.06 (14) | 6–20 (15 days) | 22 | |
| RA2705M | 15 | 0 (14) | * | Deceased | |
| RA2118F | 60 | 0.02 (14) | 8–20 (13 days) | 22 | |
| RA2267F | 15 | 0.01 (10) | * | Deceased | |
| RA1782F | 10 | 0.27 (10) | * | Deceased | |
| Meand | - | 0.063 ± 0.042 | 13.67 ± 0.67 | 21.33 ± 0.67 | |
| Range | - | 0–0.27 | 13–15 | 20–22 | |
| 7.0 | RA2597M | 15 | 0 (12) | Deceased | |
| RA2284F | 60 | 0.03 (16) | 6–22 (17 days) | 24 | |
| RA2021F | 60 | 0.02 (14) | 6–18 (13 days) | 20 | |
| RA2265F | 21 | 0.01 (12) | * | Deceased | |
| RA2257F | 15 | 0.02 (12) | * | Deceased | |
| RA0456F | 15 | 0 (12) | * | Deceased | |
| Meand | - | 0.013 ±0.0049 | 15 ± 2.0 | 22 ± 2 | |
| Range | - | 0–0.03 | 13–17 | 20–24 | |
| 7.5 | RA2700M | 60 | 0.03 (14) | 4–16 (13 days) | 18 |
| RA2709M | 60 | 0.02 (14) | 8–20 (13 days) | 22 | |
| RA2592M | 60 | 0.01 (14) | 6–18 (13 days) | 20 | |
| RA1938M | 60 | 0 (14) | 6–20 (15 days) | 22 | |
| RA2691M | 39 | 0.02 (10) | 6–16 (11 days) | 18 | |
| RA2745F | 18 | 0 (12) | * | Deceased | |
| Meand | - | 0.013 ± 0.0049 | 13 ± 0.63 | 20 ± 0.89 | |
| Range | - | 0–0.03 | 11–15 | 18–22 | |
| 8.0 | RA2596M | 60 | 0.03 (12) | 6–20 (15 days) | 22 |
| RA2816M | 17 | 0.01 (14) | * | Deceased | |
| RA2689M | 18 | 0.02 (12) | * | Deceased | |
| RA2694M | 17 | 0 (10) | * | Deceased | |
| RA2598M | 15 | 0.01 (14) | * | Deceased | |
| RA2733F | 19 | 0 (12) | * | Deceased | |
| Meandd | - | 0.012 ± 0.0048 | 15 | 22 | |
| Range | - | 0–0.03 | 22 | ||
| 8.5 | RA2685M | 25 | 0.01 (14) | * | Deceased |
| RA2475M | 20 | 0.01 (12) | * | Deceased | |
| RA2318M | 15 | 0 (10) | * | Deceased | |
| RA2743F | 60 | 0 (10) | 6–22 (17 days) | 24 | |
| RA2742F | 15 | 0.01 (12) | * | Deceased | |
| RA2116F | 14 | 0.02 (12) | * | Deceased | |
| Meand | - | 0.0083 ± 0.0031 | 17 | 24 | |
| Range | - | 0–0.02 | 24 | ||
a
Numbers outside bracket indicate neutrophil counts and numbers inside the brackets indicate study days postirradiation.
b
Numbers outside bracket indicate duration of neutropenia (first and last day) and numbers inside the brackets indicate period of neutropenia in days based on first and last neutropenic days postirradiation.
c
Numbers indicate day postirradiation on which animals recovered from neutropenia.
d
Mean data shown with the standard error of the mean (+SEM)
*
The values for these animals are not included for calculating the mean and ranges since these animals deceased prior to the end of the cytopenia period.