TABLE 4.
Platelet-Related Parameters for Rhesus Macaques after Total-Body γ Irradiation
| Dose (Gy) (≤20 × 103 /μl) | Animal ID and gender | Survival day | Thrombocytopenia |
||
|---|---|---|---|---|---|
| PLT nadir/(day)a | Duration days Postirradiationb | Recovery PLT >20 × 103/μl on dayc | |||
|
| |||||
| 6.0 | RA2580M | 60 | 0 (12) | 10–20 (11 days) | 22 |
| RA2445M | 60 | 0 (12) | 10–18 (9 days) | 20 | |
| RA0529F | 60 | 0 (14) | 12–16 (5 days) | 18 | |
| RA2740F | 60 | 0 (14) | 10–14 (5 days) | 16 | |
| RA0724F | 14 | 0 (12) | * | Deceased | |
| RA0521F | 13 | 0 (12) | * | Deceased | |
| Meand | - | 0 | 7.5 ±1.5 | 19 ±1.29 | |
| Range | - | 0 | 5–11 | 16–22 | |
| 6.5 | RA1547M | 60 | 3 (14) | 12–16 (5 days) | 18 |
| RA2576M | 60 | 15 (14) | 14–16 (3 days) | 18 | |
| RA2705M | 15 | 0 (14) | * | Deceased | |
| RA2118F | 60 | 10 (14) | 12–16 (5 days) | 18 | |
| RA2267F | 15 | 0 (14) | * | Deceased | |
| RA1782F | 10 | 8 (10) | * | Deceased | |
| Meand | - | 6 ± 2.46 | 4.3 ±0.67 | 18 | |
| Range | - | 0–15 | 3–5 | 18 | |
| 7.0 | RA2597M | 15 | 0 (12) | * | Deceased |
| RA2284F | 60 | 2 (14) | 10–14 (5 days) | 16 | |
| RA2021F | 60 | 6 (14) | 12–14 (3 days) | 16 | |
| RA2265F | 21 | 3 (14) | * | Deceased | |
| RA2257F | 15 | 7 (12) | * | Deceased | |
| RA0456F | 15 | 0 (14) | * | Deceased | |
| Meand | - | 3 ± 1.21 | 4 ±1.0 | 16 | |
| Range | - | 0–7 | 3–5 | 16 | |
| 7.5 | RA2700M | 60 | 12 (14) | 12–14 (3 days) | 16 |
| RA2709M | 60 | 4 (18) | 12–20 (11 days) | 22 | |
| RA2592M | 60 | 0 (12) | 10–16 (7 days) | 18 | |
| RA1938M | 60 | 0 (14) | 10–18 (9 days) | 20 | |
| RA2691M | 39 | 4 (14) | 10–14 (5 days) | 16 | |
| RA2745F | 18 | 0 (10) | * | Deceased | |
| Meand | - | 3.3 ± 1.91 | 7 ±1.41 | 18.4 ±1.17 | |
| Range | - | 0–12 | 3–11 | 16–22 | |
| 8.0 | RA2596M | 60 | 5 (20) | 10–24 (15 days) | 26 |
| RA2816M | 17 | 3 (12) | * | Deceased | |
| RA2689M | 18 | 2 (12) | * | Deceased | |
| RA2694M | 17 | 0 (12) | * | Deceased | |
| RA2598M | 15 | 3 (12) | * | Deceased | |
| RA2733F | 19 | 0 (12) | * | Deceased | |
| Meand | - | 2.2 ± 0.79 | 15 | 26 | |
| Range | - | 0–5 | 26 | ||
| 8.5 | RA2685M | 25 | 1 (12) | * | Deceased |
| RA2475M | 20 | 0 (20) | * | Deceased | |
| RA2318M | 15 | 0 (10) | * | Deceased | |
| RA2743F | 60 | 0 (10) | 10–26 (17 days) | 28 | |
| RA2742F | 15 | 2 (12) | * | Deceased | |
| RA2116F | 14 | 3 (12) | * | Deceased | |
| Meand | - | 1 ± 0.52 | 17 | 28 | |
| Range | - | 0–3 | 28 | ||
a
Numbers outside bracket indicate platelet counts and numbers inside the brackets indicate study days postirradiation.
b
Numbers outside bracket indicate duration of thrombocytopenia (first and last day) and numbers inside the brackets indicate period of thrombocytopenia in days based on first and last thrombocytopenic days postirradiation.
c
Numbers indicate day postirradiation on which animals recovered from thrombocytopenia.
d
Mean data shown with the standard error of the mean (+SEM)
*
The values for these animals are not included for calculating the mean and ranges since these animals deceased prior to the end of the cytopenia period.