Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 May 27;14:3069. doi: 10.1038/s41467-023-38554-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a Cross sectional scheme of the iCarP optical path. b–d Panorama (i) and magnified images (ii) of ex vivo porcine hearts illuminated by the photonic devices: FEOF in PMCL (b), TOF in PMCL (c), and iCarP (d), insets: optical fiber end structures and corresponding light scattering diagrams, (i) scale bars = 2.5 cm; (ii) scale bar = 1 cm. White arrows indicate the optical fibers. Top view (iii) and front view (iv) of 1.5 cm thick heart tissue illuminated by corresponding photonic devices (devices completely covered by the heart tissue; their locations were indicated by white circles), scale bar = 1 cm. e ICarP illumination on ex vivo porcine hearts, scale bar = 1 cm. White arrows indicate the optical fibers, black arrow indicates the location of the air gap. (i) Porcine heart illuminated by iCarP at a lower power compared to that in (d), showing the distribution of scattered light. (ii) iCarP illumination on distorted porcine heart. (iii) Cross section of iCarP and porcine myocardium in the same configuration as in (a). f, g Illumination scopes and depths of clinically used matt flat-end optical fiber (f) and side glow optical fiber (g). Panorama (i), magnified images (ii) and cross section (iii) of illuminated porcine hearts. Scale bar = 1 cm. h Timeline of the animal study. i Light absorption spectrum of AuNRs, inset: representative TEM image of > 100 AuNRs. Scale bar = 50 μm. j Infrared thermal imaging of mice illuminated by iCarP (i) and FEOF (ii). k Temperature of mice illuminated by iCarP (i) and FEOF (ii). l, m Therapeutic effect of iCarP (l) and FEOF (m) illumination (representative for n = 3 biologically independent samples). (i) Representative TUNEL staining images of illuminated tumor, scale bar = 200 μm. (ii) TUNEL staining images, scale bar = 20 μm. (iii) Representative H&E staining images of illuminated tumor, scale bar = 200 μm. (iv) Magnified H&E staining images, scale bar = 20 μm. (v) Quantitative analysis of necrosis based on H&E staining.