Table 1.
Mutation rate per haploid genome or exome per generation in P. falciparum Dd2-WT and Dd2-Polδ parasites cultured in the absence or presence of drug pressure
| Parasite lines | Number of clones | Mutation rate (Genome) | Mutation rate (Exome) | Fold-change (Genome) | Fold-change (Exome) |
|---|---|---|---|---|---|
| No drug pressure | |||||
| Dd2-WT | 12 | 6.12E-9 (4.91E-9–7.33E-9) | 1.54E-9 (1.58E-10–2.92E-9) | – | – |
| Dd2-Polδ-E8 | 12 | 9.86E-9 (7.06E-9–1.27E-8) | 7.37E-9 (3.67E-9–1.11E-8) | 1.6 | 4.8 |
| Dd2-Polδ-F11 | 14 | 1.59E-8 (1.36E-8–1.83E-8) | 1.27E-8 (9.64E-9–1.58E-8) | 2.6 | 8.2 |
| Dd2-Polδ-H11 | 11 | 1.97E-8 (1.41E-8–2.52E-8) | 1.25E-8 (9.04E-9–1.6E-8) | 3.2 | 8.1 |
| With drug pressure | |||||
| Dd2-WT | |||||
| KAE609 | 2 | 4.42E-09 (0–4.19E-8) | 4.64E-09 (0–2.99E-8) | 0.7 | 3.0 |
| Dd2-Polδ-H11 | |||||
| KAE609 | 3 | 3.72E-8 (2.63E-8–4.81E-8) | 4.42E-8 (1.11E-8–7.72E-8) | 6.1 | 28.7 |
| MMV665794 | 6 | 2.56E-8 (2.05E-8–3.08E-8) | 2.99E-8 (2.25E-8–3.73E-8) | 4.2 | 19.4 |
| Salinopostin A | 6 | 2.34E-8 (1.86E-8–2.82E-8) | 2.61E-8 (2.03E-8–3.19E-8) | 3.8 | 16.9 |
| KM15HA | 2 | 1.58E-8 (0–7.19E-8) | 1.93E-8 (4.88E-9–3.37E-8) | 2.6 | 12.5 |
Fold change was calculated by using untreated Dd2-WT as a comparator in both the no-drug and drug-pressured conditions. Values in brackets represent 95% confidence intervals, with negative values adjusted to zero. Underlying data are included in Supplementary Data 2.