Table 1.

Statistical comparison of glial marker phenotypes in organotypic slices from 1.5-month-old and 7-month-old wild-type (B6SJL) and 5xFAD mice under various treatments (Fig. 1)

Treatment	Hippocampus		Cortex
	Control	N-Aβcore	Control	N-Aβcore
Microglia: Iba1High CD68High
1.5 mo vs 7 mo B6SJL	p < 0.0001	p < 0.0001	p = 0.0002	p = 0.0016
1.5 mo vs 7 mo 5xFAD	p < 0.0001	p < 0.0001	p < 0.0001	p < 0.0001
1.5 mo B6SJL Control vs N-Aβcore		p = 0.9996		p = 0.7463
1.5 mo 5xFAD Control vs N-Aβcore		p = 0.4282		p = 0.7463
7 mo B6SJL Control vs N-Aβcore		p = 0.0296		p = 0.3023
7 mo 5xFAD Control vs N-Aβcore		p = 0.1138		p = 0.4216
Astrocytes: GFAPHigh
1.5 mo vs 7 mo B6SJL	p = 0.9632	p = 0.9996	p = 0.0946	p = 0.9997
1.5 mo vs 7 mo 5xFAD	p = 0.0003	p = 0.0124	p < 0.0001	p = 0.0620
1.5 mo B6SJL Control vs N-Aβcore		p = 0.9513		p = 0.9997
1.5 mo 5xFAD Control vs N-Aβcore		p = 0.9940		p = 0.0339
7 mo B6SJL Control vs N-Aβcore		p = 0.3343		p = 0.1082
7 mo 5xFAD Control vs N-Aβcore		p = 0.3853		p < 0.0001

p values from Tukey post hoc tests of two-way ANOVAs of number of hippocampal and cortical cells positive for the phenotypic markers