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. 2023 Mar 7;12(9):10393–10405. doi: 10.1002/cam4.5772

TABLE 1.

Significant and nominal significant MR results.

Cancer Gut microbiota SNP (n) IVW RAPS WM MR‐Egger
OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
BC Class. Actinobacteria 22 0.94 (0.89, 0.99) 0.02 0.95 (0.90, 0.996) 0.03 0.95 (0.89, 1.01) 0.09 0.99 (0.86, 1.13) 0.85
Genus. Parabacteroides 5 0.87 (0.79, 0.96) 7.31 × 10−3 0.87 (0.78, 0.98) 0.02 0.89 (0.78, 1.01) 0.08 0.91 (0.69, 1.22) 0.59
Genus. Sellimonas 11 1.05 (1.02, 1.09) 2.31 × 10−3 1.06 (1.02, 1.10) 4.86 × 10−3 1.03 (0.98, 1.08) 0.21 1.01 (0.86, 1.20) 0.09
BC (ER+) Genus. Adlercreutzia 8 0.88 (0.81, 0.95) 7.16 × 10−4 0.88 (0.81, 0.96) 2.81 × 10−3 0.90 (0.81, 0.99) 0.03 1.01 (0.72, 1.42) 0.96
Genus. Sellimonas 11 1.09 (1.05, 1.14) 2.01 × 10−5 1.09 (1.05, 1.14) 7.60 × 10−5 1.10 (1.04, 1.17) 1.24 × 10−3 1.03 (0.85, 1.25) 0.76
BC (ER‐) Genus. Dorea 11 0.84 (0.73, 0.96) 8.95 × 10−3 0.84 (0.72, 0.97) 0.02 0.82 (0.69, 0.98) 0.03 0.80 (0.57, 1.12) 0.23

Genus. Eubacterium

xylanophilum group

9 0.82 (0.71, 0.95) 7.41 × 10−3 0.81 (0.69, 0.94) 4.42 × 10−3 0.80 (0.67, 0.97) 0.02 0.77 (0.47, 1.26) 0.34
Genus. Lachnospiraceae NK4A136 group 15 0.88 (0.79, 0.97) 0.01 0.88 (0.79, 0.98) 0.02 0.86 (0.74, 0.98) 0.03 0.86 (0.70, 1.05) 0.17
EC (EH) Genus. Dorea 11 0.74 (0.60, 0.91) 3.81 × 10−3 0.71 (0.56, 0.89) 3.28 × 10−3 0.73 (0.56, 0.95) 0.02 0.61 (0.35, 1.06) 0.11
Genus. Lactobacillus 10 0.81 (0.71, 0.94) 4.01 × 10−3 0.81 (0.69, 0.95) 8.17 × 10−3 0.86 (0.72, 1.03) 0.10 0.74 (0.48, 1.15) 0.22
LC Genus. Erysipelatoclostridium 16 1.19 (1.05, 1.36) 8.85 × 10−3 1.20 (1.04, 1.39) 0.01 1.19 (0.98, 1.44) 0.07 0.91 (0.53, 1.56) 0.73
Genus. Holdemanella 11 1.22 (1.06, 1.40) 5.29 × 10−3 1.24 (1.03, 1.48) 0.02 1.23 (1.03, 1.47) 0.02 1.26 (0.83, 1.92) 0.30
LUAD Family. Peptococcaceae 10 0.70 (0.55, 0.88) 2.51 × 10−3 0.70 (0.53, 0.92) 0.01 0.73 (0.53, 0.997) 0.05 1.05 (0.59, 1.85) 0.88
Genus. Erysipelatoclostridium 16 1.37 (1.11, 1.68) 2.68 × 10−3 1.38 (1.10, 1.72) 5.46 × 10−3 1.42 (1.08, 1.87) 0.01 0.94 (0.41, 2.19) 0.89

Genus. Eubacterium

Hallii group

15 0.72 (0.56, 0.93) 0.01 0.71 (0.54, 0.94) 0.02 069 (0.49, 0.97) 0.03 0.83 (0.47, 1.49) 0.55
Genus. Gordonibacter 12 0.82 (0.71, 0.94) 5.58 × 10−3 0.81 (0.69, 0.95) 8.82 × 10−3 0.80 (0.66, 0.97) 0.03 0.50 (0.27, 0.93) 0.05
LUSC Phylum. Tenericutes 12 0.71 (0.56, 0.91) 6.00 × 10−3 0.70 (0.53, 0.92) 0.0.01 0.77 (0.56, 1.07) 0.12 1.08 (0.48, 2.39) 0.86
Class. Mollicutes 12 0.71 (0.56, 0.91) 6.00 × 10−3 0.70 (0.53, 0.92) 0.0.01 0.77 (0.56, 1.07) 0.12 1.08 (0.48, 2.39) 0.86
Genus. Flavonifractor 6 1.89 (1.23, 2.89) 3.73 × 10−3 2.00 (1.37, 2.93) 3.75 × 10−4 1.98 (1.25, 3.15) 3.69 × 10−3 1.17 (0.13, 10.47) 0.89
Genus. Ruminococcus1 8 0.59 (0.40, 0.88) 0.01 0.61 (0.36, 1.02) 0.06 0.64 (0.38, 1.10) 0.11 1.38 (0.40, 4.74) 0.62
OC Genus. Family XIIIAD3011 group 12 0.83 (0.72, 0.95) 6.50 × 10−3 0.82 (0.70, 0.95) 0.01 0.81 (0.68, 0.98) 0.03 0.65 (0.33, 1.29) 0.25
OC (HGS) Family. Alcaligenaceae 15 0.80 (0.68, 0.95) 8.94 × 10−3 0.78 (0.66, 0.94) 8.38 × 10−3 0.76 (0.61, 0.94) 0.01 0.68 (0.33, 1.37) 0.30

Genus. Christensenellaceae

R7 group

10 1.37 (1.06, 1.78) 0.02 1.36 (1.03, 1.80) 0.03 1.52 (1.13, 2.05) 5.64 × 10−3 0.83 (0.41, 1.68) 0.62

Genus. Family

XIIIAD3011 group

12 0.77 (0.65, 0.90) 1.47 × 10−3 0.76 (0.63, 0.91) 2.74 × 10−3 0.87 (0.69, 1.09) 0.23 0.51 (0.22, 1.15) 0.13
OC (LGS) Class. Clostridia 11 2.16 (1.19, 3.93) 0.01 2.42 (1.25, 4.67) 8.86 × 10−3 2.75 (1.22, 6.20) 0.01 2.70 (0.12, 60.21) 0.55
Order. Clostridiales 11 2.41 (1.33, 4.37) 3.89 × 10−3 2.72 (1.40, 5.29) 3.13 × 10−3 3.21 (1.45, 7.10) 4.00 × 10−3 2.00 (0.10, 41.04) 0.66
Genus. Alloprevotella 6 1.58 (1.13, 2.20) 7.38 × 10−3 1.60 (1.10, 2.33) 0.01 1.82 (1.16, 2.84) 8.94 × 10−3 0.83 (0.03, 21.28) 0.91
Genus. Collinsella 10 0.48 (0.28, 0.84) 9.51 × 10−3 0.47 (0.26, 0.87) 0.02 0.61 (0.29, 1.29) 0.19 0.48 (0.06, 3.98) 0.52
Genus. Ruminiclostridium5 11 2.27 (1.26, 4.07) 6.09 × 10−3 2.30 (1.20, 4.41) 0.01 1.76 (0.78, 3.94) 0.17 0.63 (0.06, 7.09) 0.72
OC (ED) Family. Streptococcaceae 14 1.58 (1.15, 2.19) 5.19 × 10−3 1.59 (1.14, 2.22) 6.66 × 10−3 1.27 (0.81, 1.99) 0.29 0.99 (0.23, 4.25) 0.99
Genus. Adlercreutzia 8 1.53 (1.15, 2.04) 3.99 × 10−3 1.55 (1.12, 2.14) 7.56 × 10−3 1.36 (0.91, 2.04) 0.14 1.82 (0.47, 7.16) 0.42
Genus. Ruminiclostridium6 16 1.36 (1.07, 1.72) 0.01 1.37 (1.05, 1.77) 0.02 1.27 (0.91, 1.78) 0.16 1.00 (0.56, 1.82) 0.99
OC (IM) Family. Peptostreptococcaceae 14 1.59 (1.10, 2.29) 0.01 1.61 (1.08, 2.40) 0.02 1.54 (0.93, 2.56) 0.10 1.00 (0.42, 2.39) 1.00
PC Class. Alphaproteobacteria 7 0.84 (0.75, 0.93) 1.11 × 10−3 0.82 (0.74, 0.91) 2.32 × 10−4 0.84 (0.74, 0.96) 8.66 × 10−3 0.79 (0.51, 1.21) 0.32
Order. Rhodospirillales 14 0.91 (0.85, 0.97) 6.24 × 10−3 0.91 (0.85, 0.98) 9.49 × 10−3 0.91 (0.84, 0.99) 0.03 0.73 (0.54, 0,98) 0.05
Genus. Adlercreutzia 8 0.89 (0.82, 0.97) 5.18 × 10−3 0.88 (0.81, 0.97) 7.81 × 10−3 0.86 (0.77, 0.96) 8.91 × 10−3 0.93 (0.63, 1.37) 0.73
Genus. Coprobacter 11 0.92 (0.87, 0.98) 8.28 × 10−3 0.92 (0.86, 0.98) 0.01 0.94 (0.87, 1.01) 0.11 1.03 (0.84, 1.26) 0.79

Abbreviations: BC, breast cancer; ER+, estrogen receptor‐positive; ER‐, estrogen receptor‐negative; EC (EH), endometrial cancer (endometrioid histology); IVW, inverse variance weighted; LC, lung cancer; LUAD, lung adenocarcinoma; LUSC, lung squamous carcinoma; OC, ovarian cancer; OC (HGS), high‐grade serous ovarian cancer; OC (LGS), low grade serous ovarian cancer; OC (ED), endometrioid ovarian cancer; OC (IM), invasive mucinous ovarian cancer; PC, prostate cancer; RAPS, robust adjusted profile score; WM, weighted median.