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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Curr Opin Microbiol. 2023 Apr 12;73:102298. doi: 10.1016/j.mib.2023.102298

Figure 3: Human cell type-specific inflammasome responses to Salmonella infection.

Figure 3:

While human macrophages employ a multifactorial inflammasome response to Salmonella infection, human intestinal epithelial cells (IECs) rely on a single inflammasome, the caspase-4/5 inflammasome, during Salmonella infection. In human macrophages, Salmonella infection induces NAIP/NLRC4, NLRP3, and caspase-4/5 inflammasome responses, facilitating IL-1 cytokine release, pyroptosis, and ultimately restriction of bacterial replication. In contrast, in human IECs undergo a caspase-4-dependent, NAIP/NLRC4- and NLRP3-independent inflammasome response to Salmonella infection.