Table 1.

Diagnosis of major depression based on DSM-5 criteria.^⁎

A. Required symptoms. At least one of the following: Depressed Mood: Most of the day, nearly every day; may be subjective (e.g., feels sad, empty, hopeless) or observed by others (e.g., appears tearful). Loss of interest: Markedly diminished interest/pleasure in all (or almost all) activities most of the day, nearly every day. B. Associated symptoms. ≥4 of the following additional symptoms during the same 2-week period that are a change from previous functioning: Weight loss or gain Insomnia or hypersomnia Psychomotor agitation or retardation Feeling worthless or excessive/inappropriate guilt Decreased concentration Thoughts of death or suicide

^*When symptoms not attributable to effects of substance abuse, underlying medical condition, or better explained by other psychiatric conditions.