Fig. 1.

Representative recordings of action potentials and firing patterns in capsaicin-sensitive bladder afferent neurons from mice. A: Action potentials evoked by 50 ms depolarizing current pulses injected through glass patch pipettes during current clamp recordings. Asterisks with dashed lines indicate the thresholds for spike activation. B: Firing patterns of action potentials during 800 ms membrane depolarization. SI; spinal intact group, SCI; spinal cord injury group, SCI + p38 MAPK group; spinal cord injury treated with p38 MAPK inhibitor (0.51 μg/h, i.t.) for two weeks. The number of neurons/mice per group is 19/13; SI, 24/11; SCI and 20/8; SCI + p38 MAPK inhibitor, respectively.