Table.
Electrophysiological properties of capsaicin sensitive bladder afferent neurons
| SI + vehicle | SCI + vehicle | SCI + p138 MAPK inhibitor | |
|---|---|---|---|
| Spikes: | |||
| Number of cells/mice | 19/13 | 24/11 | 20/8 |
| Diameter (μm) | 25.4 ± 4.8 | 29.3 ± 3.8* | 28.5 ± 3.8* |
| Input capacitance (pF) | 26.9 ± 11.6 | 36.6 ± 10.4* | 36.1 ± 10.6* |
| Resting membrane potentials (mV) | −50.0 ± 0.29 | −50.0 ± 0.68 | −50.0 ± 0.31 |
| Spike threshold (mV) | −21.5 ± 8.7 | −31.2 ± 5.2* | −19.3 ± 8.4# |
| Peak membrane potential (mV) | 39.7 ± 21.1 | 37.0 ± 15.6 | 48.5 ± 15.0# |
| Spike duration (ms) | 2.3 ± 1.0 | 3.7 ± 1.4* | 2.5 ± 1.8# |
| Number of spikes (800 ms depolarization) | 1.1 ± 0.3 | 5.3 ± 4.1* | 1.1 ± 0.3# |
| K+ current density: | |||
| Number of cells/mice | 24/9 | 24/9 | 18/7 |
| Slow decaying KA current density (pA/pF) | 48.4 ± 35.8 | 22.6 ± 14.6* | 49.4 ± 26.3# |
| Sustained KDR current density (pA/pF) | 120.7 ± 80.1 | 54.9 ± 35.4* | 63.2 ± 29.9* |
Values are means ± SD.
*
P < 0.05 and
#
P < 0.05, when compared with the Bonferroni’s method to the SI and SCI group, respectively. KA, A-type K+; KDR, delayed rectifier-type K+; SCI, mice with spinal cord injury; SI, spinal cord intact mice; SCI + p38 MAPK inhibitor, SCI mice treated with p38 Mitogen-Activated Protein Kinase inhibitor (0.51 μg per hour, i.t.) for 2 weeks.