Figure 6.

Differential expression of subsets of genes with known roles in the context of pancreatic cancer [7, 41–42, 44–48, 50–55] that is statistically significant in (a) both gem vs control and in pHIFU+gem vs gem, (b) only gem vs control, and (c) only in pHIFU+gem vs gem. Differential expression of pHIFU+gem vs control is shown for comparison where statistically significant. Most genes that are upregulated by administration of gem alone are downregulated by pHIFU, with a notable exception of PPARγ. Broadly, upregulation of these genes is associated with immunosuppression through attraction of MDSCs and tumor-associated macrophages, tumor-supporting complement system and inflammation, and chemoresistance and tumorigenesis. *p<0.05; ^†p<0.01; ^‡p<0.001