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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Amyloid. 2022 Nov 29;30(2):220–224. doi: 10.1080/13506129.2022.2148094

Figure 2.

Figure 2.

Time courses of subunit exchange between endogenous plasma WT TTR (~ 3.7 μM tetramer) and added dual-FLAG-tagged Cys10Ala TTR (FT2-C10A TTR; 1 μM tetramer) at the indicated diflunisal concentrations. (A) The x-axis shows time in hours and the y-axis depicts the fraction of exchange calculated from the area under peak 3 in the ion-exchange chromatograms. All timepoints were measured in biological triplicate. (B) The decrease in the plasma TTR subunit exchange rate constant (increase in pharmacological kinetic stabilization) correlates with the increase in plasma diflunisal concentrations.