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. 2023 May 15;14:1143451. doi: 10.3389/fimmu.2023.1143451

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Copyright © 2023 Petro-Turnquist, Pekarek, Jeanjaquet, Wooledge, Steffen, Vu and Weaver

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ad-swH3-Epi reduces viral shedding at 5 days post infection. Swine were challenged with 10⁶ TCID₅₀ of A/swine/Wyoming/A01444562/2013 by split intratracheal and intranasal inoculation. Nasal swabs were collected at 1-, 3-, and 5-days post infection and amount of viral RNA was quantified by RT-qPCR (A) and levels of infectious virus were measured by TCID₅₀ (B). Data are presented as the mean ± SEM (n=5 pigs/group; one-way ANOVA with Tukey’s multiple comparison; *p<0.05). ns, not significant.