Table 1.
Substrate specificity of the V. cholerae RND efflux systems.
| RND system | ||||||
|---|---|---|---|---|---|---|
| VexAB | VexCD | VexGH | VexIJK | VexEF | VexLM | |
| Antimicrobial peptides | yes | no | no | no | no | no |
| β-lactams | yes | no | yes | no | no | no |
| Bile acids | yes | yes | yes | no | yes* | no |
| Dyes | yes | no | no | no | yes* | no |
| Erythromycin | yes | no | no | no | yes* | no |
| Novobiocin | yes | no | yes | yes | yes* | no |
| SDS | yes | no | no | yes | no | no |
| Triton X-100 | yes | no | yes | yes | yes* | no |
*Only observed when expressed in Escherichia coli.