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. 2023 May 15;11:1115877. doi: 10.3389/fped.2023.1115877

Table 5.

Empirical antibiotic treatments and adjustment of antibiotics after the antibiogram was available.

Drug sensitivity results Adjustment of antibiotics after the antibiogram was available With underlying diseases Clinical cure
Empiric antibiotic regimens were adjusted in 30 cases
9 cases Sensitive One case was adjusted to other sensitive antibiotic due to antibiotic allergy.
Four cases were adjusted to other sensitive antibiotics after five days' ineffective treatment.
Four cases combinated with other sensitive antibiotics after three days' ineffective treatment.
6 7
5 cases Resistant Adjusted to other sensitive antibiotics 4 3
2 cases Intermediate Adjusted to other sensitive antibiotics 1 2
14 cases No done 13 cases were adjusted to other sensitive antibiotics after five days' ineffective treatment.
One case combinated with other sensitive antibiotics after three days' ineffective treatment.
8 11
Empirical antibiotics (n = 50)
Cefoperazone-sulbactam (n = 15) No done (n = 13)
Resistant (n = 1)
Intermediate (n = 1)
12 cases were adjusted to other sensitive antibiotics due to ineffective treatment.
Three cases retained the same treatment.
8 13
Meropenem (n = 14) Sensitive (n = 10)
Resistant (n = 2)
Intermediate (n = 2)
Four cases (two cases each of resistant and intermediate) were adjusted to other sensitive antibiotics due to ineffective treatment.
Four meropenem-sensitive cases were combinated with other sensitive antibiotics after three days' ineffective treatment.
Seven cases retained the same treatment.
7 8
Cefepime (n = 4) No done (n = 2)
Sensitive (n = 2)
Two cefepime-sensitive cases were combinated with other sensitive antibiotics after five days' ineffective treatment.
Two cases retained the same treatment.
3 4
TMP-SMX (n = 2) Sensitive (n = 2) Retained the same treatment. 2 2
Piperacillin tazobactam (n = 4) No done (n = 1)
Sensitive (n = 2)
Resistant (n = 1)
One case retained the same treatment.
Three cases were adjusted to other sensitive antibiotics due to ineffective treatment.
3 2
Ceftriaxone (n = 3) No done (n = 1)
Sensitive (n = 2)
Two ceftriaxone-sensitive cases were retained the same treatment.
One case was adjusted to other sensitive antibiotics due to ineffective treatment.
3 2
Ceftazidime (n = 2) Sensitive (n = 2) One case was adjusted to other sensitive antibiotic due to antibiotic allergy.
The other case was adjusted to other sensitive antibiotics after five days' ineffective treatment.
1 1
Others (n = 6) No done (n = 1)
Resistant (n = 5)
Two cases were adjusted to other sensitive antibiotics due to ineffective treatment.
Four cases retained the same treatment.
1 6

Ineffective treatment: fever persisted and clinical situation of patient continued worsening after 3–5 days' antibiotic therapy.