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NL4-3 was effectively inhibited at a 512-fold increased concentration of LP-19 over a period of up to 39 weeks. (A, B) The HIV strain NL4-3 has a mutation site in the non-NHR region, showing the concentration and time at which the mutation sites appeared. (C) Location of HIV gp41 mutation in HXB2. Wild type (amino acids above bars) to mutation type (amino acids below bars), The mutated amino acids site was in HIV gp41 region.
