Figure 5.

Loss of Cx3cr1 reduces injury accelerated cystic disease. (A) UMAP showing clusters of macrophages and dendritic cells in cystic (CM IR) and control mice (CM sham, cont IR) mice 56 days post IR injury or sham surgery. (B) Quantification of cluster composition in biological duplicates. (C, D) Pathway analysis of genes that were enriched (adjusted P value < 0.05) in (C) Ccr2⁺ KRM or (D) Cd63⁺ KRM from cystic mice compared to control mice (CM sham and cont IR). (E) Representative H&E images and quantification of cystic index in CM IR mice on the Cx3cr1 ^gfp/wt or Cx3cr1 ^gfp/gfp background 56 days post injury. **P< 0.01.