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. 2023 May 15;14:1186582. doi: 10.3389/fphar.2023.1186582

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Copyright © 2023 Yang, Kim, Shim, Ryu and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comprehensive transcriptomic analysis of the liver tissues of mice with WD-induced NAFLD. (A,B) Bulk RNA-seq analysis of whole liver tissues of mice fed with a standard diet (SD) or western diet (WD) for 24 weeks (GSE172297). Gene ontology biological processes were analyzed from the list of upregulated (A) or downregulated (B) genes in WD-fed compared to SD-fed liver tissues. (C,D) Single-cell RNA-seq (scRNA-seq) analysis of the hepatic cells of mice fed with SD or WD for 24 weeks (GSE156059). (C) Feature plot for cell types presented by uniform manifold approximation and projection (UMAP). (D) Violin plots for expression levels of genes related to indicated pathways in hepatocytes (cluster 3). AU, arbitrary unit; UMAP, uniform manifold approximation and projection.