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. 2023 May 15;14:1186582. doi: 10.3389/fphar.2023.1186582

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Copyright © 2023 Yang, Kim, Shim, Ryu and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comprehensive transcriptomic analysis of the liver tissues of patients with NAFLD. (A) Geneset enrichment analysis (GSEA) of bulk RNA-seq of whole liver tissues of healthy controls (n = 24) and patients with NAFLD (n = 20) (GSE89632). Normalized enrichment score (NES). (B) 10x Visium spatial transcriptomics analysis of liver tissues of healthy controls and patients with NAFLD (GSE192742). Each plot represents expression levels of genes related to indicated pathways depending on the region. Colors of gene symbols show that expression levels are similar (black), increased (red), or decreased (blue) in NAFLD compared to those of healthy control. AU, arbitrary unit.