Figure 5.

Allele-specific synthetic respiratory defects in cox18, mss2, and cox18, pnt1 double mutants. All strains used here contain mtDNA encoding wild-type Cox2p. Haploid strains were patched and replica plated to YPD and YPEG media and incubated at 30^o for 3 and 4 d, respectively. Wild type is boxed in the top left corner of each panel. Haploid single mutants with the indicated relevant genotypes are in the left columns and top rows outside the white lines. Double mutants contain the alleles indicated by their positions in the matrix.