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. 2023 May 15;13:1175688. doi: 10.3389/fcimb.2023.1175688

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Copyright © 2023 Bui, Luo and McBride

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of major predicted features of new immunoreactive proteins from E. chaffeensis and E. canis ORFeomes. Major immunoreactive proteins from E. chaffeensis and E. canis ORFeomes (complete set of open reading frames in the genome) are hypothetical, predicted to be T1SS or T4SS effectors, and have conformational antibody epitopes. The secretion system prediction was obtained by comprehensive bioinformatic analysis using multiple effector prediction tools. The conformation-dependent antibody epitopes have been experimentally demonstrated in most proteins.