Table 1.
Significant MR results in white Europeans.
| Class | Metabolite | Outcome | F statistic | β estimate (95% CI) |
WuH | |
|---|---|---|---|---|---|---|
| Lower Glucose | S-LDL | S-LDL-P | 2-hour post | 41.7 | -1000 (-20, -1984) |
0.017 |
| Amino Acids | Leucine | Fasting glucose | 67.3 | -0.193 (-0.069, -0.319) |
0.005 | |
| 2-hour post | -0.443 (-0.113, -0.774) |
0.008 | ||||
| M-HDL | M-HDL-CE | Fasting glucose | 62.4 | -0.327 (-0.069, -0.586) |
0.043 | |
| M-HDL-C | Fasting glucose | 117 | -0.189 (-0.021, -0.358) |
0.117 | ||
| Increase Glucose | Lipoprotein Density | HDL_D | Fasting glucose | 131 | 0.082 0.026, 0.138) |
0.004 |
| 2-hour post | 0.191 (0.043, 0.339) |
0.024 | ||||
| L-HDL | L-HDL-P | 2-hour post | 108 | 220 (41.3, 397) |
0.02 | |
| L-HDL_L | 2-hour post | 131 | 0.264 (0.062, 0,464) |
0.014 | ||
| L-HDL-C | 2-hour post | 120 | 0.279 (0.012, 0.544) |
0.048 | ||
| Cholesterol | HDL2C | 2-hour post | 103 | 0.288 (0.007, 0.583) |
0.025 | |
| HDLC | 2-hour post | 90.6 | 0.296 (0.007, 0.583) |
0.047 | ||
| HDL3C | 2-hour post | 66.6 | 1.58 (0.002, 3.15) |
0.074 | ||
| XL-HDL | XL-HDL-CE | 2-hour post | 109 | 0.541 (0.079, 1.00) |
0.039 | |
| XSVLDL | XS-VLDL-TG | 2-hour post | 87.8 | 0.841 (0.098, 1.58) |
0.042 | |
| S-HDL | S-HDL-CE | 2-hour post | 41.9 | 1.78 (0.448, 3.11) |
0.007 |
Glucose measures are expressed as mmol/L. HDL_D, mean diameter of HDLs (nm); HDLC, total cholesterol in HDL (mmol/L); HDL2C, total cholesterol in HDL2 (mmol/L); HDL3C, total cholesterol in HDL3 (mmol/L); L-HDL-C, total cholesterols in L-HDL (mmol/L); L-HDL_L, total lipids in L-HDL (mol/L); L-HDL-P, concentration of L-HDL (mol/L); M-HDL-C, total cholesterol in M-HDL (mmol/L); M-HDL-CE, cholesterol esters in M-HDL (mmol/L); S-HDL-CE, cholesterol esters in S-HDL (mmol/L); S-LDL-P, concentration of S-LDL (mol/L); XL-HDL-CE, cholesterol esters in XL-HDL (mmol/L); XS-VLDL-TG, triglycerides in XSVLDL (mmol/L); WuH, Wu-Hausman p-value.