Table 2.
Removal of potentially pleiotropic SNPs.
| Ethnicity | Metabolite | SNP | Gene | Associated confounder | Initial | Confounder removal | ||
|---|---|---|---|---|---|---|---|---|
| β estimate (95% CI) |
WuH | β estimate (95% CI) |
WuH | |||||
| WE | Leucine | rs2984433 | ACTG1P9 | BMI, Obesity class 1, weight | -0.193 (-0.319, -0.068) FG |
0.004 | -0.203 (-0.339, -0.068) FG |
0.006 |
| -0.443 (-0.774, -0.113) 2H |
0.024 | -0.547 (-0.909, -0.185) 2H |
0.002 | |||||
| L-HDL_L | rs6811162 | ENPEP | Self-reported hypertension, diagnosed high blood pressure | 0.264 (0.062, 0.464) |
0.014 | 0.301 (0.092, 0.510) |
0.006 | |
| L-HDL-C | rs5576825 | LINC01621 ELOVL4 |
Waist circumference | 0.279 (0.012, 0.544) |
0.048 | 0.323 (0.0456, 0.602) |
0.107 | |
| rs6811162 | ENPEP | Self-reported hypertension, diagnosed high blood pressure | 0.241 (-0.037, 0.519) |
0.026 | ||||
| rs5576825 + rs6811162 | - | - | 0.287 (-0.004, 0.578) |
0.063 | ||||
| XL-HDL class | rs5576825 | LINC01621 ELOVL4 |
Waist circumference | -0.285 (-0.552, -0.018) |
0.015 | -0.244 (-0.528, 0.040) |
0.135 | |
| SA | LA | rs12720820 | APOB | Self-reported high cholesterol, coronary artery disease, treatment with cholesterol lowering medication | 0.477 (0.013, 0.939) |
0.030 | 0.335 (-0.982, 0.763) |
0.459 |
| FAw6 | rs12720820 | APOB | Self-reported high cholesterol, coronary artery disease, treatment with cholesterol lowering medication | 0.445 (0.094, 0.794) |
0.007 | 0.223 (-0.398, 0.843) |
0.105 | |
| L-HDL-PL | rs7486176 | C12orf76 | Systolic blood pressure, diagnosed high blood pressure, hypertension | 0.692 (0.106, 1.28) |
0.021 | 0.853 (0.170, 1.54) |
0.013 | |
| Fatty Acid class | rs12720820 | APOB | Self-reported high cholesterol, coronary artery disease, treatment with cholesterol lowering medication | 0.172 (0.018, 0.327) |
0.018 | 0.142 (-0.049, 0.334) |
0.119 | |
2H, 2-hour post glucose; FAw6, Total n-6 fatty acids; FG, fasting glucose; LA, 18,2 linoleic acid (mmol/L); L-HDL-C, total cholesterols in L-HDL (mmol/L); L-HDL_L, total lipids in L-HDL (mmol/L); L-HDL-PL, phospholipids in L-HDL (mmol/L); SA, South Asian; WE, White European; WUH, Wu-Hausman p-value.