Table 3.
Significant MR results in South Asians.
| Class | Metabolite | Outcome | F statistic | β estimate (95% CI) |
WuH | |
|---|---|---|---|---|---|---|
| Lowers Glucose | L-LDL | LDL-P | 2-hour post | 11.7 | -2238 (-4828 -193.7) | 0.024 |
| S-LDL | SLDL-L | 2-hour post | 11.1 | -3.86 (0.467, -7.27) | 0.015 | |
| IDL | IDL-C | 2-hour post | 10.9 | -1.19 (-0.12, -2.27) | 0.021 | |
| IDL-CE | 2-hour post | 11.8 | -1.34 (-0.144, -2.55) | 0.023 | ||
| S-HDL | S-HDL-L | 2-hour post | 11.4 | -1.23 (-0.137, -2.32) | 0.012 | |
| Increases Glucose | Fatty Acids | LA | 2-hour post | 20.9 | 0.477 (0.013, 0.939) | 0.030 |
| FAw3 | Fasting glucose | 10 | 0.432 (0.063, 0.798) | 0.008 | ||
| FAw6 | 2-hour post | 33.4 | 0.445 (0.094, 0.794) | 0.007 | ||
| M-VLDL | M-VLDL-L | 2-hour post | 68.4 | 0.046 (0.009, 0.083) | 0.008 | |
| L-HDL | L-HDL-PL | 2-hour post | 43.3 | 0.692 (0.106, 1.28) | 0.021 | |
| S-HDL | S-HDL-C | Fasting glucose | 22 | 1 (0.116,1.882) | 0.012 |
Glucose measures are expressed as mmol/L. FAw3, total n-3 fatty acids; FAw6, total n-6 fatty acids; IDL-C, total cholesterols in LDL (mmol/L); IDL-CE, cholesterol esters in LDL (mmol/L); LA, 18,2 Linoleic Acid (mmol/L); LDL_P, concentration of LDL particles (mol/L); L-HDL-PL, phospholipids in L-HDL (mmol/L); M-VLDL-L, total lipids in M-VLDL (mmol/L); S-HDL-C, total cholesterols in S-HDL (mmol/L); S-HDL-L, total lipids in S-HDL (mmol/L); S-LDL-L, total lipids in S-LDL (mmol/L); WuH, Wu-Hausman p-value.