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. 2021 Dec 16;20(6):1180–1196. doi: 10.1016/j.gpb.2021.01.008

Figure 5.

Figure 5

CRISPR/Cas10-mediated multiple-gene interference in M. tuberculosis

A. Binding of multiple crRNAs to the corresponding targeted mRNAs. B. Schematic for the expression of multiple spacers, generation of multiple crRNAs, and binding of the crRNAs to the corresponding targeted mRNAs. C. Simultaneous gene expression inhibition of lpqE, katG, and inhA in the strain transformed with a plasmid containing the three spacers compared with the wild-type strain. Student’s t-test (****, P < 0.0001).