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Platelets interact with circulating monocytes by direct attachment onto the monocyte surface, by release of alpha and dense granules containing chemokines and cytokines, and by shedding of microvesicles. Monocytes in turn upregulate inflammation markers on their surface, overexpress proinflammatory transcripts, secrete chemokines and cytokines, show enhanced migration potential, and differentiate into proinflammatory macrophages. Created with BioRender.com
