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. 2023 May 15;10:960398. doi: 10.3389/fcvm.2023.960398

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© 2023 Rolling, Barrett and Berger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Visual summary on the role of MPA in cardiovascular disease. Plasma levels of circulating monocyte-platelet aggregates are increased in inflammatory diseases. Platelet-induced proinflammatory monocytes secrete inflammatory cytokines and chemokines (1), attach to and activate endothelial cells (2), show enhanced transendothelial migration potential (3), and differentiate into proinflammatory macrophages that contribute to the progression of atherosclerosis. Figure created with BioRender.com