Table 1.
Patient characteristics of Covid-19 (n = 92) and pre-pandemic IMV-patients (n = 240).
| Covid-19 cohort | Pre-pandemic cohort | p-value | ||
|---|---|---|---|---|
| Total N (%) | — | 92 (27.7) | 240 (72.3) | — |
| Age | Median (IQR) | 59.7 (51.1–64.5) | 62.0 (52.0–70.0) | 0.017 |
| Sex | Male | 65 (70.7) | 137 (57.1) | 0.032 |
| — | Female | 27 (29.3) | 103 (42.9) | — |
| Number of comorbidities | Median (IQR) | 1.0 (0.0–2.0) | 2.0 (1.0–4.0) | <0.001 |
| Comorbidities or not | No comorbidities | 35 (38.0) | 29 (12.1) | <0.001 |
| — | One or more comorbidities | 57 (62.0) | 211 (87.9) | — |
| Deprivation | Most deprived 1 | 10 (10.9) | 33 (13.8) | 0.277 |
| — | 2 | 19 (20.7) | 60 (25.0) | — |
| — | 3 | 26 (28.3) | 48 (20.0) | — |
| — | 4 | 22 (23.9) | 45 (18.8) | — |
| — | Least deprived 5 | 15 (16.3) | 54 (22.5) | — |
| Obesity | No | 62 (72.9) | 187 (77.9) | 0.434 |
| — | Yes | 23 (27.1) | 53 (22.1) | — |
| Diabetes | No | 66 (75.9) | 203 (84.6) | 0.097 |
| — | Yes | 21 (24.1) | 37 (15.4) | — |
| Asthma | No | 71 (82.6) | 197 (82.1) | 1.000 |
| — | Yes | 15 (17.4) | 43 (17.9) | — |
| Chronic pulmonary disease (not asthma) | No | 81 (94.2) | 203 (84.6) | 0.036 |
| Yes | 5 (5.8) | 37 (15.4) | ||
| Chronic cardiac disease | No | 78 (90.7) | 194 (80.8) | 0.052 |
| — | Yes | 8 (9.3) | 46 (19.2) | |
| ICU admission diagnosis category | Cardiovascular | - | 70 (29.2) | - |
| — | Respiratory | 92 (100.0) | 84 (35.0) | - |
| — | Gastrointestinal tract | - | 59 (24.6) | - |
| — | Renal | - | 3 (1.3) | - |
| — | Trauma | - | 8 (3.3) | - |
| — | Neurologic | — | 12 (5.0) | — |
| — | Miscellaneous diagnoses | - | 4 (1.7) | - |
| ISARIC-4C mortality score | Median (IQR) | 8.0 (5.0–10.0) | - | - |
| Length of hospital stay | Median (IQR) | 26.0 (15.5–40.0) | 32.0 (20.0–50.0) | 0.02 |
| ICU length of stay | Median (IQR) | - | 11.0 (6.8–18.0) | - |
| Duration of IMV | Median (IQR) | - | 8.0 (5.0–15.0) | - |
| Total SOFA score | Median (IQR) | - | 3.0 (2.0–4.0) | - |
| Respiratory SOFA score | 0 | - | 23 (9.6) | - |
| — | 1 | — | 73 (30.4) | — |
| — | 2 | — | 144 (60.) | — |
| APACHE-II score | Median (IQR) | - | 20.0 (16.0–25.0) | - |
| Time from discharge to completing CCP-UK questionnaire (days) | Median (IQR) | 185.0 (136.8–241.2) | - | - |
| 3-months survival | Yes | - | 216 (94.7) | - |
| — | No | — | 12 (5.3) | — |
| 6-month survival | Yes | - | 169 (89.4) | — |
| — | No | — | 20 (10.6) | — |
| 12-month survival | Yes | - | 163 (88.1) | — |
| — | No | — | 22 (11.9) | — |
IQR: Interquartile range; presented as 25th to 75th centiles. Numbers are presented as N (%), unless otherwise denoted as a continuous variable. ICU: Intensive Care Unit; IMV: invasive mechanical ventilation; SOFA: Sequential Organ Failure Assessment; APACHE-II: Acute Physiology and Chronic Health-II.