Figure 2.

Comparison of effect sizes of mtCN variants discovered in Longchamps et al. and their effects re-estimated in the PMBB(A) EUR cohort and (B) AFR cohort. The PMBB effect sizes were estimated using linear regression with rlrmtCN as response, variant as predictor, and 20 PCs as covariates.(C) Comparison of the effects of the same variants between the AFR and EUR cohorts. The color scale in (A) and (B) represents the minor allele frequency in the original study¹¹ and in (C) represents the difference between the AFR and EUR cohorts in the variance explained by each locus. The value in each panel represents the correlation coefficient between the two effect sizes.