Scheme 3. Synthesis of Phosphoramidate Prodrugs of l-BHDU.
Reagents and conditions: (a) l-alanine isopropyl ester hydrochloride or l-phenylalanine isopropyl ester hydrochloride, Et3N, DCM, −78 °C—rt, 3 h; (b) l-BHDU (1); NMI, THF 0 °C—rt, 12 h.
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