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. 2023 May 4;66(10):7038–7053. doi: 10.1021/acs.jmedchem.3c00545

Scheme 6. Synthesis of the Bis-POC-l-BHDU-MP Prodrug.

Scheme 6

Reagents and conditions: (a) POC-I, Cs2CO3, acetone, rt, 24 h; (b) NaI, acetonitrile, rt, 24 h; (c) POC-I, Cs2CO3, acetone, rt, 24 h; (d) Pd/C, 5-10 psi, rt, 2 h; (e) l-BHDU, BOP-Cl, 3-nitro-1, 2, 4-triazole, DIPEA, THF, rt, 2–3 h.