Table 2. Antiviral Activity of l-BHDU and Several Prodrugs against Cell-Associated Wild-Type and Mutant VZV Viruses in ARPE-19 Cells.

	EC50 (μM)
viral strains	CDV	ACV	l-BHDU	POM-l-BHDU-MP (41)	POC-l-BHDU-MP (47)	ODE-l-BHDU-MP (38)
VZV-ORF57-Luc	0.37	7.75	0.18	0.051	0.040	0.82
VZV-ORF57-ΔTK	0.42	>20	>2.0	>2.0	>2.0	>2.0
VZV-ORF57-ΔTS	0.01	0.37	0.028	0.0012	0.0084	0.0008
VZV-ORF57-ΔTKTS	1.05	>20	>2.0	>2.0	>2.0	>2.0