Table 3. Pharmacokinetic Parameters after Oral Application of 22.5 mg/kg POM-l-BHDU-MP and 11.4 mg/kg l-BHDU to BALB/c Mice.a.
| l-BHDU derived from POM-l-BHDU-MP | l-BHDU | |
|---|---|---|
| AUC (μg·min/mL) | 1680 | 764 |
| Tmax (min) | 40 | 120 |
| Cmax (μg/mL) | 10.6 | 7.1 |
LC-MS quantification of l-BHDU from POM-l-BHDU-MP- and l-BHDU-treated mice. AUC: area under the curve from 0 to 120 min; Tmax: time taken to reach maximum conc.; and Cmax: maximum concentration.