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. 2023 May 4;66(10):7038–7053. doi: 10.1021/acs.jmedchem.3c00545

Table 3. Pharmacokinetic Parameters after Oral Application of 22.5 mg/kg POM-l-BHDU-MP and 11.4 mg/kg l-BHDU to BALB/c Mice.a.

  l-BHDU derived from POM-l-BHDU-MP l-BHDU
AUC (μg·min/mL) 1680 764
Tmax (min) 40 120
Cmax (μg/mL) 10.6 7.1
a

LC-MS quantification of l-BHDU from POM-l-BHDU-MP- and l-BHDU-treated mice. AUC: area under the curve from 0 to 120 min; Tmax: time taken to reach maximum conc.; and Cmax: maximum concentration.