Figure 5.

Spectinamide-1599 concentrations in plasma and lung after 4 or 8 weeks of treatment in Mtb infected mice. Spectinamide-1599 concentrations (mean ± SD) were measured in chronically Mtb infected BALB/c mice (n = 3–5) in plasma 0.5 or 72 h and in lung homogenate 72 h after the last dose of either 4 or 8 weeks of intrapulmonary aerosol administration with 10, 50, or 200 mg/kg 3 times weekly. The shaded areas for the 0.5 h plasma concentrations are the 95% confidence intervals for the expected concentrations based on the multiple dose pharmacokinetic studies in healthy mice.