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. 2023 May 29;22:88. doi: 10.1186/s12943-023-01792-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — IGF2BP1 deletion and inhibition by BTNYB impairs xenograft tumor growth. a, b The viability and caspase3/7-activity of parental (Ctrl) and I1-KO BE(2)-C was analyzed in spheroid growth (a, n = 3) and anoikis-resistance studies (b, n = 4; bars a, 200 µm and b, 400 µm). c-e Tumor growth (n = 6) of Ctrl and I1-KO BE(2)-C s.c. xenografts was monitored by non-invasive infrared imaging (c), tumor-free survival (d) and final tumor mass (e). f RT-qPCR analysis of MYCN mRNA levels in excised xenograft tumors and non-palpable tumor cell mass upon I1-KO (Ctrl, n = 5; I1-KO, n = 2). g, h Tumor growth (n = 6) of Ctrl and I1-KO (g) or DMSO- and BTYNB-pretreated (h) BE(2)-C xenografts was monitored by tumor volume over time. i Tumor growth (n = 6) was monitored by relative volume of s.c. PDX tumors treated i.p. with DMSO (grey) or BTYNB (blue). Daily treatment in three cycles is indicated by dashed lines below the x-axis. j Tumor growth (n = 9) was monitored by relative volume of s.c. BE(2)-C treated i.t. with DMSO (grey) or 50 mg/kg BW BTYNB (blue). Daily treatment in two cycles is indicated by dashed lines below the x-axis. k Representative images of tumors at start (day 0) and final treatment (day 8)