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Vav activates Rac but not Cdc42 in response to FcγR-mediated phagocytosis. (A) Kinetics of GTP loading on Rac and Cdc42 in COS cells after induction of FcγR-directed phagocytosis. Coexpression of Vav-C blocks activation of endogenous Rac but not Cdc42. Fold activation of Rac (B) and Cdc42 (C) based on the 10-min time point is shown relative to levels of Rac and Cdc42 in the total cell lysate. Data shown are the mean ± SEM of at least three independent experiments.
