Skip to main content
. 2002 Apr;13(4):1215–1226. doi: 10.1091/mbc.02-01-0002

Figure 7.

Figure 7

FcγR-induced recruitment and activation of Rac is independent of Cdc42 function. Recruitment of GFP-Rac to nascent phagosomes in COS cells coexpressing FcγR and either empty vector (A–D) or myc-tagged N17Cdc42 (E–H). GFP-Rac (A and E), myc (B and F), and RBC (C and G) were stained and appear green, red, and blue, respectively, on the merged images (D and H). Arrows indicate sites of GFP-Rac recruitment. Images are representative of cells from at least three independent experiments. Bars, 10 μm. (I) GTP-loading on Rac in response to FcγR-induced phagocytosis is not blocked by inhibiting Cdc42 function with N17Cdc42 or the Cdc42 binding domain of Wasp (aa 201–310).