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. Author manuscript; available in PMC: 2023 May 29.
Published in final edited form as: Gene. 2020 Dec 15;770:145356. doi: 10.1016/j.gene.2020.145356

Table 4.

Top pathways and their associated p-values. P-values are presented by using Fisher’s method, and then corrected for multiple comparisons using false discovery rate (FDR) and Bonferroni corrections.

Pathway Name Pathway ID p-value p-value (FDR) p-value (Bonferroni)
African trypanosomiasis 5143 3.88426E-06 0.00058652 0.000586524
Malaria 5144 3.89219E-05 0.00293860 0.005877213
Cytokine-cytokine receptor interaction 4060 0.000153046 0.00770329 0.023109898
Adrenergic signaling in cardiomyocytes 4261 0.002860454 0.08140411 0.43192861
PI3K-Akt signaling pathway 4151 0.002980936 0.08140411 0.450121393
Cardiac muscle contraction 4260 0.003234601 0.08140411 0.488424716
Ras signaling pathway 4014 0.004489364 0.08219767 0.677894016
Gastric acid secretion 4971 0.004643523 0.08219767 0.701172005
Ether lipid metabolism 565 0.004899199 0.08219767 0.739779028

The p-value corresponding to the pathway was computed using only overrepresentation analysis. Bonferroni reduces the false discovery rate by imposing a stringent threshold on each comparison adjusted for the total number of comparisons.