TABLE 2.

Summary and synthesis of results based on HR status and meningioma characteristics

	1-Way ANOVA			Subgroup Meta-Analysis		IPD-g–Only Meta-Analysis		Mixed-Effects Meta-Regression
	OR	95% CI	p Value	OR	95% CI	OR	95% CI	OR	95% CI	p Value
PR+
Pt age	1.00	1.00–1.00	0.02	—	—	—	—	1.11	1.09–1.13	<0.0001
Female sex	1.15	1.09–1.211	<0.0001	1.84	1.47–2.29	—	—	0.80	0.41–1.54	0.50
Low grade	1.28	1.19–1.39	<0.0001	3.64	2.22–5.96	—	—	8.09	3.55–18.44	<0.0001
Meningothelial	1.12	1.06–1.19	<0.0001	—	—	1.86	1.23–2.81	1.28	0.63–2.59	0.49
Skull base	1.12	1.04–1.20	0.0028	—	—	1.89	1.03–3.48	1.08	0.54–2.16	0.83
Spinal	1.09	0.98–1.20	0.122	—	—	1.23	0.21–7.40	0.68	0.31–1.46	0.32
Detection method (IHC)	0.98	0.94–1.03	0.54	*	*	—	—	—	—	—
Year published	0.99	1.00–1.00	0.44	—	—	—	—	1.21	1.16–1.27	<0.0001
ER+
Pt age	1.00	1.00–1.00	0.44	—	—	—	—	0.99	0.98–1.00	0.48
Female sex	1.04	0.86–1.05	0.84	1.20	0.70–2.06	—	—	1.05	0.92–1.12	0.09
Meningothelial	1.04	0.99–1.10	0.11	—	—	1.84	1.18–2.86	0.94	0.86–0.98	0.044
Convexity	1.06	1.03–1.10	0.0008	—	—	1.84	0.99–3.42	1.12	1.05–1.18	0.0003
Detection method (IHC)	0.88	0.85–0.92	<0.0001	*	*	—	—	0.47	0.42–0.52	<0.0001
Year published	0.99	0.98–1.00	0.08	—	—	—	—	1.01	1.01–1.02	<0.0001
AR+
Pt age	1.01	1.00–1.01	0.071	—	—	—	—	1.00	0.99–1.01	0.71
Female sex	3.53	1.61–7.74	0.002	4.16	1.62–10.69	—	—	1.12	0.90–1.41	0.32
Fibrous	8.57	1.80–40.80	0.002	—	—	7.12	0.32–160.16	1.05	0.80–1.38	0.72
Detection method (IHC)	1.13	0.95–1.35	0.18	*	*	—	—	4.63	3.06–7.00	<0.0001
Year published	0.99	0.98–1.00	0.08	—	—	—	—	1.24	1.19–1.29	<0.0001

Boldface type indicates statistical significance.

^*Test for subgroup differences when assessing PR⁺ proportion of IHC compared to LB (χ² = 0.01, p = 0.91), ER⁺ (χ² = 4.87, p = 0.03), or AR⁺ (χ² = 0, p = 0.99).