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. 2022 Sep 13;25(3):309–313. doi: 10.4103/aja202262

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(a) Serum estradiol levels and (b) serum total testosterone levels investigated at baseline and follow-up visit for control (white bars) and case (gray bars) subjects (n=12 for each group). Control subjects did not undergo oophorectomy and were maintained on the same testosterone dose. Serum estradiol level was significantly decreased at the follow-up period postoophorectomy compared to transmasculine individuals who did not undergo oophorectomy (^*P = 0.03). No significant difference was found between testosterone levels at baseline or follow-up. ^*P < 0.05. Data are presented as mean ± standard error of the mean. NS: not significant.