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The START domain potentiates HD-ZIPIII transcriptional activity. Without a START domain, HD-ZIPIII TFs make fewer and less transcriptionally potent dimers (left), while mutations that prevent ligand binding at the START domain abolish DNA binding (right). START mutations marked (right). These data propose a model in which a functional START domain promotes HD-ZIPIII dimerization and transcriptional potency but requires a ligand for these TFs to bind DNA (middle).
